Antithymocyte Globulin: Immunosuppressive therapy

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The drug Antithymocyte Globulin is sold under the brand name Thymogam. Antithymocyte globulin is a lymphocyte-selective immunosuppressant as demonstrated by its ability to reduce the number of circulating, thymus-dependent lymphocytes forming rosettes with sheep erythrocytes. The drug Antithymocyte Globulin sterile solution might appear colorless to faintly pink or brown and is nearly odorless. It might develop a slight granular or flaky deposit during storage. Human red blood cells are used in manufacturing to deplete cross-reactive antibodies to non–T-cell antigens. The manufacturing process is validated to remove or inactivate potential exogenous viruses. All human red blood cells are from U.S.-registered or FDA-licensed blood banks. Antithymocyte globulin (ATGAM) is a purified, pasteurized immunoglobulin G obtained by immunizing rabbits with human thymocytes. This immunosuppressive product contains cytotoxic antibodies directed against antigens expressed on human T-lymphocytes.

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