I've personally always wondered this. As a big anime fan, I've wondered what the ninja in Naruto would do with crippling illness, or what they'd do in Blood+ if Saya ever ran out of spoons for the day.
PMDD, Hashimoto's Thyroidism, IBS, ezcema, tendinitus, joint pain, depression, insomnia, panic attacks, migraines, a sensitive bladder, shy veins, ADD, chronic memory loss, sensitivity to light, and I'm going deaf.